Vitex agnus-castus Ze 440 extract in the therapy of cyclic mastodynia in women with non-tumor breast damage

Cyclic mastalgia of varying intensity occurs every month in at least 70% women, persistent pain the mammary glands moderate and severe degree is occur about 50% patients with benign mastopathy. The cause mastodynia morphofunctional rearrangement glandular stromal components tissues expansion ducts proliferation epithelial structures due to a lack progesterone an increase prolactin levels. Therapy for cyclical chronic empirical not always effective. Herbal medicine Vitex agnus-castus reasonable alternative hormonal treatment women suffering from cyclic combination other manifestations premenstrual syndrome. main effect such drugs luteinizing hormone synthesis, on hypothalamic-pituitary system, endorphins release, which can level endogenous opioids.Purpose study: study phytopreparation Prefemin (Vitex extract Ze 440) syndrome diffuse non-tumor breast lesion. Materials methods. involved 30 aged 22 43 years various types diseases chest lasting 3 months. In 12 there was fibroadenoma, 18 – cystofibroadenoma (small cystic variant) duct ectasia.Results. (Ze allowed completely eliminate 93.3% reduce frequency group severity 90.0% fibroadenoma cystofibroadenoma.Conclusions. Phytopreparation Prefemin, obtained medicinal plant agnus-castus, has demonstrated high efficacy fibrocystic disease. This drug well tolerated were no side effects.